A Sodium Channel Blocker, Pilsicainide, Produces Atrial Post-Repolarization Refractoriness through the Reduction of Sodium Channel Availability
نویسندگان
چکیده
منابع مشابه
A sodium channel blocker, pilsicainide, produces atrial post-repolarization refractoriness through the reduction of sodium channel availability.
Atrial fibrillation (AF) is the most common tachyarrhythmia. Shortening of atrial action potential duration (APD) and effective refractory period (ERP) is one of the crucial factors in the occurrence and maintenance of AF. ERP is usually shorter than APD, but ERP can be prolonged beyond action potential repolarization in some situations. It is termed as post-repolarization refractoriness (PRR) ...
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متن کاملdocking studies of phthalimide pharmacophore as a sodium channel blocker
objective(s): recently, phthalimide derivatives were designed based on ameltolide and thalidomide as they possess a similar degree of anticonvulsant potency due to their phenytoin-like profile. the ability of phthalimide pharmacophore to interact with neuronal voltage-dependent sodium channels was studied in the batrachotoxin affinity assay. therefore, in the present study, a series of 19 compo...
متن کاملDocking Studies of Phthalimide Pharmacophore as a Sodium Channel Blocker
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ژورنال
عنوان ژورنال: The Tohoku Journal of Experimental Medicine
سال: 2011
ISSN: 0040-8727,1349-3329
DOI: 10.1620/tjem.225.35